PTCL
Belinostat is currently in a registrational trial, under a special protocol assessment, as a monotherapy for PTCL.
Disease Overview
Peripheral T-cell lymphoma (PTCL) comprises a group of rare and aggressive non-Hodgkin lymphomas that develop from T-cells in different stages of maturity. The World Health Organization (WHO) has divided the various types of PTCL into two main categories:
- Precursor T/NK neoplasms : which include precursor T-lymphoblastic leukemia/lymphoma and blastic NK lymphoma
- Peripheral T/NK neoplasms : which are subcategorized as predominantly leukemic, predominantly nodal, predominantly extranodal and subcutaneous panniculitis T-cell.
Peripheral T-cell lymphoma generally affects people over age 60 and is diagnosed in slightly more men than women.
Types of Peripheral T-Cell Lymphomas
- Peripheral T-Cell Lymphoma (Unspecified)
- Precursor T Lymphoblastic Leukemia/Lymphoma
- Blastic NK-Cell Lymphoma
- T-Cell Leukemias
- Angioimmunoblastic T-Cell Lymphoma
- Anaplastic Large-Cell Lymphoma
- Nasal T-Cell Lymphoma
- Enteropathy-Type T-Cell Lymphoma
- Hepatosplenic Gamma-Delta T-Cell Lymphoma
This information is provided courtesy of the Lymphoma Research Foundation (www.lymphoma.org)
